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Showing 1 to 12 of 73 entries
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What time is it? A tale of three clocks, with implications for personalized medicine.

Journal of pineal research

Klerman EB, Rahman SA, St Hilaire MA.
PMID: 32155668
J Pineal Res. 2020 May;68(4):e12646. doi: 10.1111/jpi.12646. Epub 2020 Mar 25.

No abstract available.

Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.

Journal of pineal research

Shin YY, Seo Y, Oh SJ, Ahn JS, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Sung ES, Kim HS.
PMID: 34826168
J Pineal Res. 2021 Nov 26;e12779. doi: 10.1111/jpi.12779. Epub 2021 Nov 26.

The prevalence of head and neck squamous cell carcinoma (HNSCC) has continued to rise for decades. However, drug resistance to chemotherapeutics and relapse, mediated by cancer stem cells (CSCs), remains a significant impediment in clinical oncology to achieve successful...

In-person vs home schooling during the COVID-19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence.

Journal of pineal research

Stone JE, Phillips AJK, Chachos E, Hand AJ, Lu S, Carskadon MA, Klerman EB, Lockley SW, Wiley JF, Bei B, Rajaratnam SMW.
PMID: 34273194
J Pineal Res. 2021 Jul 17;e12757. doi: 10.1111/jpi.12757. Epub 2021 Jul 17.

During the COVID-19 pandemic, schools around the world rapidly transitioned from in-person to remote learning, providing an opportunity to examine the impact of in-person vs remote learning on sleep, circadian timing, and mood. We assessed sleep-wake timing using wrist...

Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2.

Journal of pineal research

Cecon E, Izabelle C, Poder SL, Real F, Zhu A, Tu L, Ghigna MR, Klonjkowski B, Bomsel M, Jockers R, Dam J.
PMID: 34586649
J Pineal Res. 2021 Sep 29;e12772. doi: 10.1111/jpi.12772. Epub 2021 Sep 29.

As the COVID-19 pandemic grows, several therapeutic candidates are being tested or undergoing clinical trials. Although prophylactic vaccination against SARS-CoV-2 infection has been shown to be effective, no definitive treatment exists to date in the event of infection. The...

Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response.

Journal of pineal research

Zerbini G, Merrow M, Winnebeck EC.
PMID: 34689364
J Pineal Res. 2022 Jan;72(1):e12777. doi: 10.1111/jpi.12777. Epub 2021 Nov 08.

We read with interest the commentary by Skeldon and Dijk about our article "Weekly, seasonal and chronotype-dependent variation of dim light melatonin onset." The discussion points raised by Skeldon and Dijk are currently among the most hotly debated in...

The role of homeobox gene-encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model.

Journal of pineal research

Hertz H, Blancas-Velazquez AS, Rath MF.
PMID: 34129741
J Pineal Res. 2021 Jun 15;e12753. doi: 10.1111/jpi.12753. Epub 2021 Jun 15.

Homeobox genes encode transcription factors controlling development; however, a number of homeobox genes are expressed postnatally specifically in melatonin-producing pinealocytes of the pineal gland and photoreceptors of the retina along with transcripts devoted to melatonin synthesis and phototransduction. Homeobox...

The fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight.

Journal of pineal research

Guo J, Bai Y, Wei Y, Dong Y, Zeng H, Reiter RJ, Shi H.
PMID: 34936113
J Pineal Res. 2021 Dec 22;e12784. doi: 10.1111/jpi.12784. Epub 2021 Dec 22.

Melatonin is widely involved in plant disease resistance through modulation of immune responses. Pathogenesis-related (PR) proteins play important roles in plant immune responses. However, the direct association between melatonin biosynthetic enzyme and PR protein remains elusive in plants. In...

Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice.

Journal of pineal research

Zhang C, Clough SJ, Adamah-Biassi EB, Sveinsson MH, Hutchinson AJ, Miura I, Furuse T, Wakana S, Matsumoto YK, Okanoya K, Hudson RL, Kato T, Dubocovich ML, Kasahara T.
PMID: 34085306
J Pineal Res. 2021 Jun 04;e12748. doi: 10.1111/jpi.12748. Epub 2021 Jun 04.

The hormone melatonin is synthesized from serotonin by two enzymatic reactions (AANAT and ASMT/HIOMT) in the pineal gland following a circadian rhythm with low levels during the day and high levels at night. The robust nightly peak of melatonin...

Fetal malnutrition is associated with impairment of endogenous melatonin synthesis in pineal via hypermethylation of promoters of protein kinase C alpha and cAMP response element-binding.

Journal of pineal research

Han T, Jiang W, Wu H, Wei W, Lu J, Lu H, Xu J, Gu W, Guo X, Wang Y, Ruan J, Li Y, Wang Y, Jiang X, Zhao S, Li Y, Sun C.
PMID: 34486775
J Pineal Res. 2021 Dec;71(4):e12764. doi: 10.1111/jpi.12764. Epub 2021 Sep 22.

This study investigated whether and how fetal malnutrition would influence endogenous melatonin synthesis, and whether such effect of fetal malnutrition would transmit to the next generation. We enrolled 2466 participants and 1313 of their offspring. The urine 6-hydroxymelatonin sulfate...

The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males.

Journal of pineal research

Albreiki MS, Middleton B, Hampton SM.
PMID: 34582575
J Pineal Res. 2021 Dec;71(4):e12770. doi: 10.1111/jpi.12770. Epub 2021 Oct 09.

The suppression of melatonin by light at night (LAN) has been associated with a disruption of SCN function and biological processes. This study aimed to explore the impact of melatonin on glucose and lipid metabolism before and after a...

Retraction.

Journal of pineal research

[No authors listed]
PMID: 31657077
J Pineal Res. 2019 Nov;67(4):e12612. doi: 10.1111/jpi.12612. Epub 2019 Oct 18.

Fan, C., Pan, Y., Yang, Y., Di, S., Jiang, S., Ma, Z., Li, T., Zhang, Z., Li, W., Li, X., Reiter, R. J. and Yan, X. (2015), HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via...

Corrigendum.

Journal of pineal research

[No authors listed]
PMID: 31657078
J Pineal Res. 2019 Nov;67(4):e12609. doi: 10.1111/jpi.12609. Epub 2019 Oct 04.

No abstract available.

Showing 1 to 12 of 73 entries